| First Author | Shen S | Year | 2017 |
| Journal | Nat Neurosci | Volume | 20 |
| Issue | 9 | Pages | 1213-1216 |
| PubMed ID | 28714953 | Mgi Jnum | J:258038 |
| Mgi Id | MGI:6116625 | Doi | 10.1038/nn.4606 |
| Citation | Shen S, et al. (2017) Gut microbiota is critical for the induction of chemotherapy-induced pain. Nat Neurosci 20(9):1213-1216 |
| abstractText | Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients undergoing chemotherapy. We found that gut microbiota promotes the development of chemotherapy-induced mechanical hyperalgesia. Oxaliplatin-induced mechanical hyperalgesia was reduced in germ-free mice and in mice pretreated with antibiotics. Restoring the microbiota of germ-free mice abrogated this protection. These effects appear to be mediated, in part, by TLR4 expressed on hematopoietic cells, including macrophages. |
