| First Author | Keightley PD | Year | 1998 |
| Journal | Genetics | Volume | 148 |
| Issue | 4 | Pages | 1931-9 |
| PubMed ID | 9560406 | Mgi Jnum | J:47544 |
| Mgi Id | MGI:1203757 | Doi | 10.1093/genetics/148.4.1931 |
| Citation | Keightley PD (1998) Genetic basis of response to 50 generations of selection on body weight in inbred mice. Genetics 148(4):1931-9 |
| abstractText | A long-established inbred strain of mice was divergently selected for body weight for 50 generations. Selection of new mutations affecting the trait eventually led to a divergence of approximately three phenotypic standard deviations between the high and low lines. Heritability for body weight increased at a rate between 0.23% and 0.57% per generation from new mutations, depending on the genetic model assumed. About two-thirds of the selection response was in the upward direction. The response was episodic, suggesting a substantial contribution from the selection of mutations with large effects on the trait. A maximum likelihood procedure was used to estimate the number of factors contributing to the response using data from line crosses, with models of n equivalent gene effects (i.e., to estimate the Wright-Castle index), or n genes with variable effects. The results of the analysis of data from a cross between the selected high line and an unselected control line indicated that two major factors were involved, with the suggestion of an additional minor factor. |
