First Author | Wu M | Year | 2003 |
Journal | Mamm Genome | Volume | 14 |
Issue | 5 | Pages | 323-34 |
PubMed ID | 12856284 | Mgi Jnum | J:83137 |
Mgi Id | MGI:2657062 | Doi | 10.1007/s00335-002-2248-6 |
Citation | Wu M, et al. (2003) Cloning, functional study and comparative mapping of Luzp2 to mouse chromosome 7 and human chromosome 11p13-11p14. Mamm Genome 14(5):323-34 |
abstractText | A novel leucine-zipper gene, leucine zipper protein 2 (Luzp2), has been cloned as part of an aberrant deletion-fusion transcript in the chromosomal interval between Gas2 and Herc2 on mouse Chromosome 7 (Chr 7). Luzp2 is normally expressed only in brain and spinal cord. The human homolog of Luzp2 maps to Chr 11p13-11p14 by radiation-hybrid mapping and is deleted in some patients with Wilms tumor-Aniridia-Genitourinary anomalies-mental Retardation (WAGR) syndrome. Disruption of Luzp2 by gene targeting in mice did not result in any obvious abnormal phenotypes. |