| First Author | Moriggl R | Year | 1999 |
| Journal | Immunity | Volume | 11 |
| Issue | 2 | Pages | 225-30 |
| PubMed ID | 10485657 | Mgi Jnum | J:98326 |
| Mgi Id | MGI:3577956 | Doi | 10.1016/s1074-7613(00)80097-7 |
| Citation | Moriggl R, et al. (1999) Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity 11(2):225-30 |
| abstractText | The activation and subsequent proliferation of peripheral T cells requires the engagement of the T cell and a cytokine receptor, typically the IL-2 or IL-4 receptors. Critical to understanding the regulation of peripheral T cells is the knowledge of the unique contributions of each receptor to full T cell activation and cell cycle progression. Mice deficient in Stat5a and Stat5b have demonstrated the essential role that these highly related proteins play in cell cycle progression following peripheral T cell activation. Here we demonstrate that activation of the Stat5 proteins by tyrosine phosphorylation is uniquely contributed by cytokine receptor signaling and specifically does not occur through the T cell receptor complex. |
