| First Author | Nakatsugi S | Year | 1997 |
| Journal | Jpn J Cancer Res | Volume | 88 |
| Issue | 12 | Pages | 1117-20 |
| PubMed ID | 9473726 | Mgi Jnum | J:45606 |
| Mgi Id | MGI:1195761 | Doi | 10.1111/j.1349-7006.1997.tb00337.x |
| Citation | Nakatsugi S, et al. (1997) Suppression of intestinal polyp development by nimesulide, a selective cyclooxygenase-2 inhibitor, in Min mice. Jpn J Cancer Res 88(12):1117-20 |
| abstractText | Nonsteroidal anti-inflammatory drugs (NSAIDs) suppress colon carcinogenesis in man and experimental animals. However, conventional NSAIDs inhibit both cyclooxygenase (COX) isoforms, COX-1 and COX-2, and cause gastrointestinal side-effects. Nimesulide, a selective inhibitor of COX-2, is much less ulcerogenic. We, therefore, examined its influence on the development of intestinal polyps in Min mice. Female Min mice at 4 weeks old were given 400 ppm nimesulide in their diet for 11 weeks. This treatment resulted in a significant reduction of the numbers of both small and large intestinal polyps, the total being 52% of that in untreated control Min mice. The size of the polyps in the nimesulide-treated group was also significantly decreased. The results suggest that nimesulide is a good candidate as a chemopreventive agent for human colon cancer with low toxicity. |
