| First Author | Ziegler CC | Year | 2004 |
| Journal | J Nutr | Volume | 134 |
| Issue | 1 | Pages | 5-10 |
| PubMed ID | 14704285 | Mgi Jnum | J:88124 |
| Mgi Id | MGI:3029144 | Doi | 10.1093/jn/134.1.5 |
| Citation | Ziegler CC, et al. (2004) Dietary resveratrol does not affect intestinal tumorigenesis in Apc(Min/+) mice. J Nutr 134(1):5-10 |
| abstractText | To determine its effect on intestinal tumorigenesis and the protumorigenic COX pathway in Apc(Min/+) mice, resveratrol was administered as a powdered admixture in the diet at 0, 4, 20, or 90 mg/kg body weight for 7 wk. In two separate experiments, resveratrol did not affect intestinal tumor load. It was stable in the diet under experimental conditions, circulated in the plasma as the glucuronide-conjugated form and reached the tumors as evidenced by significant decreases in PGE2 levels. However, immunohistochemical staining of intestinal tumors revealed no changes in COX-2 expression. This study demonstrates that resveratrol consumed ad libitum in the diet, does not modify tumorigenesis in Apc(Min/+) mice. |
