| First Author | Ellender M | Year | 2005 |
| Journal | Radiat Res | Volume | 163 |
| Issue | 5 | Pages | 552-6 |
| PubMed ID | 15850417 | Mgi Jnum | J:98647 |
| Mgi Id | MGI:3579587 | Doi | 10.1667/rr3335 |
| Citation | Ellender M, et al. (2005) Direct single gene mutational events account for radiation-induced intestinal adenoma yields in apc(min/+) mice. Radiat Res 163(5):552-6 |
| abstractText | Ellender, M., Harrison, J. D., Edwards, A. A., Bouffler, S. D. and Cox, R. Direct Single Gene Mutational Events Account for Radiation-Induced Intestinal Adenoma Yields in Apc(Min/+) Mice. Radiat. Res. 163, 552-556 (2005).Data on the induction of small intestinal tumors, predominantly adenomas, by X radiation in Apc(Min/+) mice are reported. Comparison of these incidences with estimates of radiation-induced direct single gene mutation frequencies taken from the literature support the hypothesis that direct mutational loss of Apc(+) is the sole requirement for initiation of adenoma. Furthermore, estimates of radiation-induced initiation of adenoma per target stem cell in this animal model are similar to or less than radiation-induced direct somatic gene mutation frequencies. Therefore, while the data reported here do not preclude a role for genomic instability in tumor progression, it is not necessary in this model to postulate the involvement of radiation-induced transmissible genomic instability in initiation of intestinal adenoma. |
