| Primary Identifier | MGI:109355 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 20907 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables SNARE binding activity and calcium channel inhibitor activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of synaptic vesicle priming; and signal release. Acts upstream of or within calcium-ion regulated exocytosis. Located in several cellular components, including axon; nuclear membrane; and secretory vesicle. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex. Is expressed in several structures, including central nervous system; intercostal muscle; male reproductive gland or organ; retina; and spinal nerve. Used to study disease of mental health. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease and Hirschsprung's disease. Orthologous to human STX1A (syntaxin 1A). PHENOTYPE: Homozygous mice for one targeted mutation display impairments in LTP, cued fear memory consolidation and cued fear memory extinction while mice with another targeted mutation show no behavioral abnormalities. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
