| First Author | Sebzda E | Year | 2008 |
| Journal | Nat Immunol | Volume | 9 |
| Issue | 3 | Pages | 292-300 |
| PubMed ID | 18246069 | Mgi Jnum | J:131810 |
| Mgi Id | MGI:3774678 | Doi | 10.1038/ni1565 |
| Citation | Sebzda E, et al. (2008) Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns. Nat Immunol 9(3):292-300 |
| abstractText | The migration patterns of naive and activated T cells are associated with the expression of distinct sets of chemokine receptors, but the molecular basis for this regulation is unknown. Here we identify Krupple-like factor 2 (KLF2) as a key transcriptional factor needed to prevent naive T cells from expressing inflammatory chemokine receptors and acquiring the migration patterns of activated T cells. Lineage-specific deletion of KLF2 resulted in fewer naive T cells in the blood and secondary lymphoid organs, whereas it expanded naive T cell numbers in nonlymphoid tissues; these effects were associated with altered expression of inflammatory chemokine receptors on naive T cells. KLF2 repressed the expression of several chemokine receptors, including CCR3 and CCR5. We thus conclude that KLF2 maintains proper T cell migration patterns by linking T cell movement and transcriptional regulation of chemokine receptor expression patterns. |
