| First Author | Nelson BH | Year | 2004 |
| Journal | J Immunol | Volume | 172 |
| Issue | 7 | Pages | 3983-8 |
| PubMed ID | 15034008 | Mgi Jnum | J:88679 |
| Mgi Id | MGI:3036913 | Doi | 10.4049/jimmunol.172.7.3983 |
| Citation | Nelson BH (2004) IL-2, regulatory T cells, and tolerance. J Immunol 172(7):3983-8 |
| abstractText | IL-2 is a potent T cell growth factor that for many years was assumed to amplify lymphocyte responses in vivo. Accordingly, IL-2 has been used clinically to enhance T cell immunity in patients with AIDS or cancer, and blocking Abs to the IL-2R are used to inhibit T cell responses against transplanted tissues. It was later shown in mice that, unexpectedly, disruption of the IL-2 pathway results in lymphoid hyperplasia and autoimmunity rather than immune deficiency, indicating that the major physiological function of IL-2 is to limit rather than enhance T cell responses. This apparent paradox has recently been resolved with the discovery that IL-2 is critical for the development and peripheral expansion of CD4(+)CD25(+) regulatory T cells, which promote self-tolerance by suppressing T cell responses in vivo. Our new understanding of IL-2 biology prompts a re-evaluation of how best to clinically manipulate this important immunoregulatory pathway. |
