| First Author | Bisbach CM | Year | 2020 |
| Journal | Cell Rep | Volume | 31 |
| Issue | 5 | Pages | 107606 |
| PubMed ID | 32375026 | Mgi Jnum | J:293105 |
| Mgi Id | MGI:6445298 | Doi | 10.1016/j.celrep.2020.107606 |
| Citation | Bisbach CM, et al. (2020) Succinate Can Shuttle Reducing Power from the Hypoxic Retina to the O2-Rich Pigment Epithelium. Cell Rep 31(5):107606 |
| abstractText | When O2 is plentiful, the mitochondrial electron transport chain uses it as a terminal electron acceptor. However, the mammalian retina thrives in a hypoxic niche in the eye. We find that mitochondria in retinas adapt to their hypoxic environment by reversing the succinate dehydrogenase reaction to use fumarate to accept electrons instead of O2. Reverse succinate dehydrogenase activity produces succinate and is enhanced by hypoxia-induced downregulation of cytochrome oxidase. Retinas can export the succinate they produce to the neighboring O2-rich retinal pigment epithelium-choroid complex. There, succinate enhances O2 consumption by severalfold. Malate made from succinate in the pigment epithelium can then be imported into the retina, where it is converted to fumarate to again accept electrons in the reverse succinate dehydrogenase reaction. This malate-succinate shuttle can sustain these two tissues by transferring reducing power from an O2-poor tissue (retina) to an O2-rich one (retinal pigment epithelium-choroid). |
