| First Author | Kang JS | Year | 2002 |
| Journal | EMBO J | Volume | 21 |
| Issue | 1-2 | Pages | 114-24 |
| PubMed ID | 11782431 | Mgi Jnum | J:72468 |
| Mgi Id | MGI:2152959 | Doi | 10.1093/emboj/21.1.114 |
| Citation | Kang JS, et al. (2002) BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. EMBO J 21(1-2):114-24 |
| abstractText | CDO is a cell surface receptor-like protein that positively regulates myogenic differentiation. Reported here is the identification of BOC, which, with CDO, defines a newly recognized subfamily within the immunoglobulin superfamily. cdo and boc are co-expressed in muscle precursors in the developing mouse embryo. Like CDO, BOC accelerates differentiation of cultured myoblast cell lines and participates in a positive feedback loop with the myogenic transcription factor, MyoD. CDO and BOC form complexes in a cis fashion via association of both their ectodomains and their intracellular domains. A soluble fusion protein that contains the entire BOC ectodomain functions similarly to full-length BOC to promote myogenic differentiation, indicating that the intracellular region is dispensable for its activity in this system. Furthermore, a dominant-negative form of CDO inhibits the pro-myogenic effects of soluble BOC, suggesting that BOC is dependent on CDO for its activity. CDO and BOC are proposed to be components of a receptor complex that mediates some of the cell-cell interactions between muscle precursors that are required for myogenesis. |
