| First Author | Turner J | Year | 2001 |
| Journal | Exp Gerontol | Volume | 36 |
| Issue | 3 | Pages | 537-45 |
| PubMed ID | 11250124 | Mgi Jnum | J:68120 |
| Mgi Id | MGI:1932160 | Doi | 10.1016/s0531-5565(00)00257-6 |
| Citation | Turner J, et al. (2001) The progression of chronic tuberculosis in the mouse does not require the participation of B lymphocytes or interleukin-4. Exp Gerontol 36(3):537-45 |
| abstractText | The aging process is associated with alterations in the immune system. Some of the changes reported are an increase in the proportion of B lymphocytes, and a shift to a TH2-like cytokine environment. It has been hypothesized that the development of immunopathology within the lung during tuberculosis is linked to increased interleukin-4 (IL-4) production. In addition, a role for B cells in maintaining granuloma integrity has been recently proposed. This study investigated the role of B cells and IL-4 during the long-term course of chronic tuberculosis in mice and showed that the course of Mycobacterium tuberculosis infection in the lungs was not influenced by the absence of B lymphocytes or the TH2 cytokine IL-4. |
