| Primary Identifier | MGI:2182351 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Cyp1a2 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The insertion of an hprt gene, with the opposite orientation of the endogenous gene, deleted a portion of exon 2 and all of exons 3 through 5. This deleted region encoded the conserved cysteine-containing fragment and the cytochrome P450 tridecapeptide. Northern blot analysis of total hepatic RNA obtained from beta-naphthoflavone-treated animals showed a lack of transcript in homozygous mutant mice. Failure of homozygous mutant mice to metabolize zoxazolamine, a muscle relaxant, indicated a lack of functional protein. |
