| First Author | Wang WW | Year | 1994 |
| Journal | Gene | Volume | 143 |
| Issue | 2 | Pages | 261-4 |
| PubMed ID | 8206384 | Mgi Jnum | J:18730 |
| Mgi Id | MGI:66969 | Doi | 10.1016/0378-1119(94)90107-4 |
| Citation | Wang WW, et al. (1994) Sequence of the 5'-flanking region of the rat c-fos proto-oncogene. Gene 143(2):261-4 |
| abstractText | The proto-oncogene c-fos is an immediate-early gene that becomes activated by a wide variety of extracellular stimuli. Since many studies regarding regulation of c-fos are conducted in vivo using rats, or with rat cell lines, we have cloned the rat c-fos gene in order to verify that the same regulatory elements that have been characterized in the human and mouse c-fos promoter are also present and functional in the rat. The nucleotide (nt) sequence of the 5'-flanking region of the rat c-fos gene displays remarkable similarity with the mouse and human c-fos genes (93 and 77% identity, respectively). cis-Acting regulatory elements, such as the sis-inducible element (SIE), serum-response element (SRE), AP-1-recognition site, calcium/cAMP-response element (Ca/CRE) and TATA box are present in the rat c-fos 5'-flanking region. A putative glucocorticoid-response element (GRE) is present 13 bp downstream from the AP-1-recognition site. |
