First Author | Zhang N | Year | 2000 |
Journal | Genomics | Volume | 63 |
Issue | 1 | Pages | 142-4 |
PubMed ID | 10662554 | Mgi Jnum | J:60562 |
Mgi Id | MGI:1353673 | Doi | 10.1006/geno.1999.6055 |
Citation | Zhang N, et al. (2000) Cloning, expression, and chromosomal localization of a mouse gene homologous to the germ cell migration regulator wunen and to type 2 phosphatidic acid phosphatases. Genomics 63(1):142-4 |
abstractText | The wunen gene of Drosophila melanogaster encodes a multipass membrane-spanning protein that negatively regulates primordial germ cell migration. Here we describe the cloning of a mouse gene that encodes a protein homologous to wunen and to the Type 2 phosphatidic acid phosphatases. This gene encodes a 251-amino-acid protein that most closely resembles the human Type 2 phosphatidic acid phosphatase PAP-2c. Northern blot analysis revealed the presence of a single 1.9-kb Ppap2c transcript. The Ppap2c gene was localized to the central portion of mouse Chromosome 10 by interspecific backcross analysis. Copyright 2000 Academic Press. |