| Primary Identifier | MGI:104685 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 13345 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor activity; chromatin binding activity; and protein domain specific binding activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within several processes, including face morphogenesis; negative regulation of cell differentiation; and negative regulation of macromolecule biosynthetic process. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; embryo mesenchyme; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in Barber-Say syndrome and ablepharon macrostomia syndrome. Orthologous to human TWIST2 (twist family bHLH transcription factor 2). PHENOTYPE: Deletion of this gene results in high postnatal lethality. Progressive growth retardation is observed with adipose tissue deficiency, skin, hair and muscle abnormalities, as well as hematopoietic and lymphoid organ defects including the spleen, thymus, and liver. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
