| First Author | Yamamoto A | Year | 2000 |
| Journal | Genesis | Volume | 27 |
| Issue | 2 | Pages | 49-57 |
| PubMed ID | 10890978 | Mgi Jnum | J:63695 |
| Mgi Id | MGI:1861478 | Citation | Yamamoto A, et al. (2000) Mouse paraxial protocadherin is expressed in trunk mesoderm and is not essential for mouse development. Genesis 27(2):49-57 |
| abstractText | Paraxial protocadherin (PAPC) is a cell adhesion molecule that marks cells undergoing convergence-extension cell movements in Xenopus and zebrafish gastrulating embryos. Here a mouse homologue (mpapc) was identified and characterized. During early- to mid-gastrulation, mpapc is expressed in the primitive streak as the trunk mesoderm undergoes morphogenetic cell movements. At head-fold stage mpapc expression becomes localized to paraxial regions in which somites are formed in the segmental plate. At later stages, mpapc displays a complex expression pattern in cerebral cortex, olfactory bulb, inferior colliculus, and in longitudinal stripes in hindbrain. To analyze the effect of the loss of PAPC function during mouse development, a null allele of the mouse papc gene was generated. Homozygous animals show no defects in their skeleton and are viable and fertile. |
