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Allele : Adk<tm1Bois> adenosine kinase; targeted mutation 1, Detlev Boison

Primary Identifier  MGI:2449557 Allele Type  Targeted
Attribute String  Null/knockout, Reporter Gene  Adk
Inheritance Mode  Recessive Transmission  Germline
Strain of Origin  129P3/JEmsJ Is Recombinase  false
Is Wild Type  false
description  The lethality and hepatic steatosis associated with homozygosity for this mutation are rescued by a transgene expressing adenosine kinase under control of the human ubiquitin promoter, despite the protein's low expression in the liver. (J:105483)
molecularNote  This gene was disrupted by the in frame insertion of GFP containing expression cassette. Western analysis was used to demonstrate a lack of protein in homozygous mutant mice.
  • mutations:
  • Insertion
  • synonyms:
  • fb-Adk-def,
  • Adk-,
  • fb-Adk-def,
  • Adk-
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

Trail: Allele

0 Driven By

16 Publication categories

Trail: Allele