Primary Identifier | MGI:2449557 | Allele Type | Targeted |
Attribute String | Null/knockout, Reporter | Gene | Adk |
Inheritance Mode | Recessive | Transmission | Germline |
Strain of Origin | 129P3/JEmsJ | Is Recombinase | false |
Is Wild Type | false |
description | The lethality and hepatic steatosis associated with homozygosity for this mutation are rescued by a transgene expressing adenosine kinase under control of the human ubiquitin promoter, despite the protein's low expression in the liver. (J:105483) |
molecularNote | This gene was disrupted by the in frame insertion of GFP containing expression cassette. Western analysis was used to demonstrate a lack of protein in homozygous mutant mice. |