| Primary Identifier | MGI:7547368 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Sema4d |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Lysine codon 848 (AAG) in exon 16 (in ENSMUST00000021900) was changed to threonine (ACG) (p.K848T) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation is the equivalent of the human p.K849T mutation which has been identified as the first causal mutation for primary sclerosing cholangitis (PSC). |
