|  Help  |  About  |  Contact Us

Protein Coding Gene : Pfn2 profilin 2

Primary Identifier  MGI:97550 Organism  mouse, laboratory
Chromosome  3 NCBI Gene Number  18645
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable ATP hydrolysis activity; actin monomer binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including negative regulation of ruffle assembly; positive regulation of stress fiber assembly; and synapse organization. Acts upstream of or within positive regulation of actin filament polymerization and regulation of synaptic vesicle exocytosis. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynapse. Is expressed in several structures, including central nervous system; cornea stroma; ganglia; hemolymphoid system gland; and tooth. Orthologous to human PFN2 (profilin 2).
PHENOTYPE: Mice homozygous for a knock-out allele display increased synaptic excitability of neocortical glutamatergic neurons due to higher vesicle exocytosis, hyperactivation of the striatum, hyperactivity, and increased novelty-seeking behavior. [provided by MGI curators]
  • synonyms:
  • profilin 2,
  • MGD-MRK-13250,
  • MGD-MRK-13248,
  • profilin,
  • Pfn,
  • Pfn2

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

9 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For