Primary Identifier | MGI:97550 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 18645 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable ATP hydrolysis activity; actin monomer binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including negative regulation of ruffle assembly; positive regulation of stress fiber assembly; and synapse organization. Acts upstream of or within positive regulation of actin filament polymerization and regulation of synaptic vesicle exocytosis. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynapse. Is expressed in several structures, including central nervous system; cornea stroma; ganglia; hemolymphoid system gland; and tooth. Orthologous to human PFN2 (profilin 2). PHENOTYPE: Mice homozygous for a knock-out allele display increased synaptic excitability of neocortical glutamatergic neurons due to higher vesicle exocytosis, hyperactivation of the striatum, hyperactivity, and increased novelty-seeking behavior. [provided by MGI curators] |