| First Author | Seeger A | Year | 1996 |
| Journal | Mol Immunol | Volume | 33 |
| Issue | 6 | Pages | 511-20 |
| PubMed ID | 8700167 | Mgi Jnum | J:34322 |
| Mgi Id | MGI:81782 | Doi | 10.1016/0161-5890(96)00002-8 |
| Citation | Seeger A, et al. (1996) A complement factor B-like cDNA clone from the zebrafish (Brachydanio rerio). Mol Immunol 33(6):511-20 |
| abstractText | An important molecule in the activation of the complement system in vertebrates is factor B, a serine protease with a molecular mass of 95,000. Factor B and the complement component C2 are thought to have arisen by gene duplication. In mammals and in Xenopus the factor B gene is linked to the major histocompatibility complex (MHC), whereas in domestic fowl it segregates independently of the MHC. Here we describe the isolation of a cDNA clone coding for factor B in the zebrafish, Brachydanio rerio. The deduced protein sequence exhibits a characteristic mosaic structure consisting of the short consensus repeat (SCR), the von Willebrand factor, and the serine protease domains. The estimated time of factor B and C2 divergence (approximately 350 million years ago), combined with the fact that C2 has thus far been found only in mammals, suggest that the factor B-C2 gene duplication occurred after the divergence of mammal-like reptiles from other reptiles and hence also birds. After the duplication, the C2 component evolved significantly faster than factor B. |
