Primary Identifier | MGI:1346330 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 23825 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables DNA binding activity. Acts upstream of or within DNA integration. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of chromatin. Predicted to be active in condensed chromosome and nucleus. Human ortholog(s) of this gene implicated in Nestor-Guillermo progeria syndrome. Orthologous to human BANF1 (BAF nuclear assembly factor 1). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts fail to hatch from the zona pellucida and die after 3 days in culture. [provided by MGI curators] |