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Allele : Pcsk9<tm1.2Prat> proprotein convertase subtilisin/kexin type 9; targeted mutation 1.2, Annik Prat
Primary Identifier  MGI:4943496 Allele Type  Targeted
Attribute String  Null/knockout Gene  Pcsk9
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  The proximal promoter and exon 1 were flanked by loxP sites and an FRT flanked neomycin selection cassette was inserted just downstream of the loxP site in intron 1. The neomycin selection cassette was subsequently excised by flp recombinase expression after crossing to Gt(ROSA)26Sor mice and cre expression after crossing to Tg(CMV-cre)1Ipc mice resulted in excision of the proximal promoter and exon 1.
  • mutations:
  • Insertion,
  • Intragenic deletion
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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13 Publication categories

Trail: Allele




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