| First Author | Obara N | Year | 1993 |
| Journal | Anat Embryol (Berl) | Volume | 188 |
| Issue | 1 | Pages | 13-20 |
| PubMed ID | 8214621 | Mgi Jnum | J:15524 |
| Mgi Id | MGI:63644 | Doi | 10.1007/BF00191447 |
| Citation | Obara N, et al. (1993) Expression of the neural cell adhesion molecule (NCAM) during second- and third-molar development in the mouse. Anat Embryol (Berl) 188(1):13-20 |
| abstractText | Distribution of the neural cell adhesion molecule (NCAM) during the development of the mandibular second- and third-molars of the mouse was studied by indirect immunofluorescence techniques. At the initial stage, NCAM was intensely expressed by the mesenchymal cells surrounding the dental lamina, and by the cap stage NCAM expression by the mesenchymal cells became restricted to the dental follicle. After that, in addition to the follicular mesenchyme, some cells in the basal part of the dental papilla showed NCAM-immunoreactivity for a while after the hard tissue formation had started. During root formation, the follicular cells lost NCAM first from the level of the cervical root and later from the coronal part, while an additional NCAM positive area appeared deep in the dental papilla. Even after the teeth had erupted, NCAM was expressed in the tissue surrounding the apical root and in the pulp core. During the initial and bud stages, the pattern of NCAM expression in the second and third molars was different from that in the first molar, where NCAM was found only after the late bud stage; while from the cap stage onward, it changed in the same sequence as in the first molar. The different pattern of NCAM expression implies that there is a difference in developmental events between the early stages of the first and the other two molars. On the other hand, the common sequence of NCAM expression in the tooth germs later than the cap stage suggests that NCAM plays an essential role in the formation of the basic structure of the teeth and periodontal tissues. |
