| First Author | Siarey RJ | Year | 1999 |
| Journal | Neuropharmacology | Volume | 38 |
| Issue | 12 | Pages | 1917-20 |
| PubMed ID | 10608287 | Mgi Jnum | J:86821 |
| Mgi Id | MGI:2682135 | Doi | 10.1016/s0028-3908(99)00083-0 |
| Citation | Siarey RJ, et al. (1999) Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome. Neuropharmacology 38(12):1917-20 |
| abstractText | Long-term potentiation (LTP) and depression (LTD) were investigated in hippocampus of a genetic model of Down syndrome, the segmental trisomy (Ts65Dn) mouse. Field excitatory postsynaptic potentials were recorded from hippocampal slices and LTP and LTD evoked sequentially. LTP decreased whereas LTD increased significantly in Ts65Dn compared with control hippocampus. |
