Primary Identifier | MGI:87887 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 110834 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables acetylcholine-gated monoatomic cation-selective channel activity. Acts upstream of or within several processes, including behavioral response to nicotine; chemical synaptic transmission; and regulation of acetylcholine secretion, neurotransmission. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse and postsynaptic specialization membrane. Is expressed in several structures, including central nervous system; gut; myenteric nerve plexus; paravertebral ganglion; and retina. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; lung cancer (multiple); nicotine dependence; and stomach cancer. Orthologous to human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit). PHENOTYPE: Homozygotes for a targeted null mutation show high postnatal and postweaning mortality. Mutants show reduced bladder contractility resulting in enlarged bladder, infections and urinary stones. Eyes are small, with dilated ocular pupils. [provided by MGI curators] |