| First Author | Pape KA | Year | 2011 |
| Journal | Science | Volume | 331 |
| Issue | 6021 | Pages | 1203-7 |
| PubMed ID | 21310965 | Mgi Jnum | J:169132 |
| Mgi Id | MGI:4939933 | Doi | 10.1126/science.1201730 |
| Citation | Pape KA, et al. (2011) Different B cell populations mediate early and late memory during an endogenous immune response. Science 331(6021):1203-7 |
| abstractText | Memory B cells formed in response to microbial antigens provide immunity to later infections; however, the inability to detect rare endogenous antigen-specific cells limits current understanding of this process. Using an antigen-based technique to enrich these cells, we found that immunization with a model protein generated B memory cells that expressed isotype-switched immunoglobulins (swIg) or retained IgM. The more numerous IgM(+) cells were longer lived than the swIg(+) cells. However, swIg(+) memory cells dominated the secondary response because of the capacity to become activated in the presence of neutralizing serum immunoglobulin. Thus, we propose that memory relies on swIg(+) cells until they disappear and serum immunoglobulin falls to a low level, in which case memory resides with durable IgM(+) reserves. |
