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Publication : Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling.

First Author  Cho G Year  2008
Journal  Mol Cell Biol Volume  28
Issue  5 Pages  1565-72
PubMed ID  18160706 Mgi Jnum  J:132651
Mgi Id  MGI:3776604 Doi  10.1128/MCB.01038-07
Citation  Cho G, et al. (2008) Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling. Mol Cell Biol 28(5):1565-72
abstractText  Bone morphogenic proteins (BMPs) play pleotrophic roles in nervous system development, and their signaling is highly regulated at virtually every step in the pathway. We have cloned a novel gene, Sizn1 (Smad-interacting zinc finger protein), which functions as a transcriptional coactivator of BMP signaling. It positively modulates BMP signaling by interacting with Smad family members and associating with CBP in the transcription complex. Sizn1 is expressed in the ventral embryonic forebrain, where, as we will show, it contributes to BMP-dependent, cholinergic-neuron-specific gene expression. These data indicate that Sizn1 is a positive modulator of BMP signaling and provide further insight into how BMP signaling can be modulated in neuronal progenitor subsets to influence cell-type-specific gene expression and development.
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