| First Author | Underhill DM | Year | 1998 |
| Journal | J Biol Chem | Volume | 273 |
| Issue | 50 | Pages | 33619-23 |
| PubMed ID | 9837946 | Mgi Jnum | J:115146 |
| Mgi Id | MGI:3690736 | Doi | 10.1074/jbc.273.50.33619 |
| Citation | Underhill DM, et al. (1998) MacMARCKS is not essential for phagocytosis in macrophages. J Biol Chem 273(50):33619-23 |
| abstractText | MacMARCKS (also known as myristoylated alanine-rich protein kinase C substrate (MARCKS)-related protein) is a member of the MARCKS family of protein kinase C substrates. MacMARCKS contains within it a basic effector domain that contains the serine residues that are phosphorylated by protein kinase C, as well as a calcium/calmodulin and actin-binding site. Two previous reports demonstrated that a macrophage cell line expressing a mutant form of MacMARCKS that lacks the effector domain is defective in phagocytosis and cell adhesion (Zhu, Z., Bao, Z., and Li, J. (1995) J. Biol. Chem. 270, 17652-17655; Li, J., Zhu, Z., and Bao, Z. (1996) J. Biol. Chem. 271, 12985-12990). We report here that macrophages from MacMARCKS null mice phagocytose and spread normally. Thus, although MacMARCKS is recruited to phagosomes, it is not absolutely required for phagocytosis. |
