| First Author | Kim MY | Year | 2003 |
| Journal | Immunity | Volume | 18 |
| Issue | 5 | Pages | 643-54 |
| PubMed ID | 12753741 | Mgi Jnum | J:83470 |
| Mgi Id | MGI:2662067 | Doi | 10.1016/s1074-7613(03)00110-9 |
| Citation | Kim MY, et al. (2003) CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells. Immunity 18(5):643-54 |
| abstractText | In this report we identify an accessory cell that interacts with primed and memory T cells at sites where they collaborate with B cells. These cells are distinguished from conventional dendritic cells by their lack of response to Flt3 ligand and their inability to process antigen. Unlike dendritic cells, the CD4(+)CD3(-) cells have little CD80 or CD86 expression but do express high levels of the TNF ligands, OX40 ligand and CD30 ligand. We show that Th2-primed cells express the receptors for these TNF ligands and preferentially survive when cocultured with these cells. Furthermore, we show that the preferential survival of OX40(+) T cells and support of memory T cell help for B cells are linked to their association with CD4(+)CD3(-) cells in vivo. |
