Primary Identifier | MGI:109609 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 14073 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables acylglycerol lipase activity. Predicted to be involved in fatty acid catabolic process; monoacylglycerol catabolic process; and positive regulation of vasoconstriction. Predicted to act upstream of or within lipid catabolic process. Predicted to be located in organelle membrane. Is expressed in several structures, including brain; ganglia; gut; olfactory epithelium; and renal calyx. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Orthologous to human FAAH (fatty acid amide hydrolase). PHENOTYPE: Homozygotes for a null allele show high brain anandamide (AEA) levels, reduced pain sensation, altered behavioral responses to AEA, and sex-specific changes in ethanol intake and sensitivity. Homozygotes for the C385A variant show enhanced cued fear extinction and reduced anxiety-like behavior. [provided by MGI curators] |