| First Author | He L | Year | 2003 |
| Journal | Blood | Volume | 102 |
| Issue | 10 | Pages | 3652-7 |
| PubMed ID | 12893751 | Mgi Jnum | J:86451 |
| Mgi Id | MGI:2679911 | Doi | 10.1182/blood-2003-04-1323 |
| Citation | He L, et al. (2003) The contributions of the alpha 2 beta 1 integrin to vascular thrombosis in vivo. Blood 102(10):3652-7 |
| abstractText | The alpha 2 beta 1 integrin serves as a receptor for collagens, laminin, and several other nonmatrix ligands. Many studies have suggested that the alpha 2 beta 1 integrin is a critical mediator of platelet adhesion to collagen within the vessel wall after vascular injury and that the interactions of the platelet alpha 2 beta 1 integrin with subendothelial collagen after vascular injury are required for proper hemostasis. We have used the alpha 2 beta 1 integrin-deficient mouse to evaluate the contributions of the alpha 2 beta 1 integrin in 2 in vivo models of thrombosis. Studies using a model of endothelial injury to the carotid artery reveal that the alpha 2 beta 1 integrin plays a critical role in vascular thrombosis at the blood-vessel wall interface under flow conditions. In contrast, the alpha 2 beta 1 integrin is not required for the formation of thrombi and pulmonary emboli following intravascular injection of collagen. Our results are the first to document a critical in vivo role for the alpha 2 beta 1 integrin in thrombus formation at the vessel wall under conditions of shear following vascular injury. |
