| First Author | Kwon HB | Year | 2008 |
| Journal | Neuron | Volume | 57 |
| Issue | 1 | Pages | 108-20 |
| PubMed ID | 18184568 | Mgi Jnum | J:135355 |
| Mgi Id | MGI:3793417 | Doi | 10.1016/j.neuron.2007.11.024 |
| Citation | Kwon HB, et al. (2008) Long-term potentiation selectively expressed by NMDA receptors at hippocampal mossy fiber synapses. Neuron 57(1):108-20 |
| abstractText | The mossy fiber to CA3 pyramidal cell synapse (mf-CA3) provides a major source of excitation to the hippocampus. Thus far, these glutamatergic synapses are well recognized for showing a presynaptic, NMDA receptor-independent form of LTP that is expressed as a long-lasting increase of transmitter release. Here, we show that in addition to this 'classical' LTP, mf-CA3 synapses can undergo a form of LTP characterized by a selective enhancement of NMDA receptor-mediated transmission. This potentiation requires coactivation of NMDA and mGlu5 receptors and a postsynaptic calcium rise. Unlike classical LTP, expression of this mossy fiber LTP is due to a PKC-dependent recruitment of NMDA receptors specifically to the mf-CA3 synapse via a SNARE-dependent process. Having two mechanistically different forms of LTP may allow mf-CA3 synapses to respond with more flexibility to the changing demands of the hippocampal network. |
