| First Author | Ilić D | Year | 1997 |
| Journal | Carcinogenesis | Volume | 18 |
| Issue | 8 | Pages | 1473-6 |
| PubMed ID | 9276618 | Mgi Jnum | J:42336 |
| Mgi Id | MGI:1095615 | Doi | 10.1093/carcin/18.8.1473 |
| Citation | Ilic D, et al. (1997) Skin abnormality in aged fyn-/- fak+/- mice. Carcinogenesis 18(8):1473-6 |
| abstractText | Focal adhesion kinase (FAK) is a novel non-receptor protein tyrosine kinase implicated in transducing signals from cell surface receptors. Its association with Fyn, a member of the Src family of tyrosine kinases, has been observed in cell lines. To examine in vivo the interaction between these two proteins, Fyn-deficient mice were bred with fak heterozygous mutants (Fak deficiency is embryonic lethal). A majority of animals with the double mutation (fyn-/- fak+/-) displayed a transient impairment in thymocyte development at four weeks of age. However, all of them developed skin abnormalities at the age of 8-12 months. The most prominent among abnormalities was a greatly increased number and size of sebaceous glands. Also, the epidermis was thickened and hyperkeratotic. These observations would suggest involvement of Fyn and FAK in keratinocyte differentiation. |
