| First Author | Hsu DK | Year | 1993 |
| Journal | Biochem Biophys Res Commun | Volume | 197 |
| Issue | 3 | Pages | 1483-91 |
| PubMed ID | 7506544 | Mgi Jnum | J:34252 |
| Mgi Id | MGI:81717 | Doi | 10.1006/bbrc.1993.2644 |
| Citation | Hsu DK, et al. (1993) Fibroblast growth factor-1 induces phosphofructokinase, fatty acid synthase and Ca(2+)-ATPase mRNA expression in NIH 3T3 cells. Biochem Biophys Res Commun 197(3):1483-91 |
| abstractText | Polypeptide growth factors act in part by inducing the expression of specific proteins that perform functions critical to cell cycle progression. We have used a differential display technique to identify genes that are expressed at higher levels following fibroblast growth factor (FGF)-1 (acidic FGF) stimulation of quiescent murine NIH 3T3 fibroblasts. Three such genes--liver (B-type) phosphofructokinase (PFK), fatty acid synthase (FAS) and sarco(endo)plasmic reticulum Ca(2+)-ATPase type 2 (SERCA2)--are described in this report. The level of FAS and SERCA2 mRNA expression is increased rapidly after FGF-1 addition; in contrast, PFK mRNA is induced with kinetics more typical of delayed-early genes. These results indicate that enhanced expression of the PFK, FAS and SERCA2 proteins may be important for FGF-1-stimulated cell proliferation. |
