Primary Identifier | MGI:1916417 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 329251 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable enzyme inhibitor activity and phosphatase regulator activity. Predicted to be involved in signal transduction. Located in A band and Z disc. Orthologous to human PPP1R12B (protein phosphatase 1 regulatory subunit 12B). PHENOTYPE: Mice with loss of expression in adult cardiomyocytes display blunted cardiac hypertrophic response to pressure overload. Mice homozygous for a null allele on a C57BL/6N background display improved cardiac function. [provided by MGI curators] |