| First Author | Lien YH | Year | 1998 |
| Journal | Am J Physiol | Volume | 274 |
| Issue | 2 Pt 1 | Pages | L301-4 |
| PubMed ID | 9486217 | Mgi Jnum | J:46053 |
| Mgi Id | MGI:1197036 | Doi | 10.1152/ajplung.1998.274.2.L301 |
| Citation | Lien YH, et al. (1998) Respiratory acidosis in carbonic anhydrase II-deficient mice. Am J Physiol 274(2 Pt 1):L301-4 |
| abstractText | To investigate the role of carbonic anhydrase (CA) II on pulmonary CO2 exchange, we analyzed arterial blood gases from CA II-deficient and normal control mice. CA II-deficient mice had a low arterial blood pH (7.18 +/- 0.06) and HCO3- concentration ([HCO3-]; 17.5 +/- 1.9 meq/l) and a high Pco2 (47.4 +/- 5.3 mmHg), consistent with mixed respiratory and metabolic acidosis. To eliminate the influence of metabolic acidosis on arterial blood gases, NaHCO3 (4 mmol/kg body weight) was given intraperitoneally, and arterial blood gases were analyzed 4 h later. Normal mice had a small increase in pH and were able to maintain Pco2 and [HCO3-]. The metabolic acidosis in CA II-deficient mice was corrected ([HCO3-], 22.9 +/- 2.4 meq/l), and respiratory acidosis became more profound (Pco2, 50.4 +/- 2.4 mmHg). These results indicate that CA II-deficient mice have a partial respiratory compensation for metabolic acidosis. We conclude that CA II-deficient mice have a mixed respiratory and metabolic acidosis. It is most likely that CO2 retention in these animals is due to CA II deficiency in both red blood cells and type II pneumocytes. |
