| First Author | Mazaki Y | Year | 2006 |
| Journal | Nat Immunol | Volume | 7 |
| Issue | 7 | Pages | 724-31 |
| PubMed ID | 16715100 | Mgi Jnum | J:112663 |
| Mgi Id | MGI:3662982 | Doi | 10.1038/ni1349 |
| Citation | Mazaki Y, et al. (2006) Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2. Nat Immunol 7(7):724-31 |
| abstractText | In neutrophils, superoxide anion production generally accompanies chemotaxis and functions in killing invading pathogens. The GIT2 GTPase-activating protein binds to the guanine nucleotide-exchange factor alphaPIX. Here we show that GIT2 was necessary for directional chemotaxis and for the suppression of superoxide production in G protein-coupled receptor-stimulated neutrophils. GIT2 was also necessary for the orientation of superoxide production toward chemoattractant sources. GIT2 suppressed the activity of ADP ribosylation factor 1 and was a component of the Gbetagamma subunit-mediated direction-sensing machinery 'downstream' of G protein-coupled receptor signaling. This study establishes a function for GIT2 in linking chemotaxis and superoxide production in neutrophils and shows that loss of GIT2 in vivo leads to an immunodeficient state. |
