| First Author | Riley JK | Year | 2006 |
| Journal | Reproduction | Volume | 131 |
| Issue | 5 | Pages | 823-35 |
| PubMed ID | 16672348 | Mgi Jnum | J:108600 |
| Mgi Id | MGI:3624388 | Doi | 10.1530/rep.1.00645 |
| Citation | Riley JK, et al. (2006) Glucose utilization and the PI3-K pathway: mechanisms for cell survival in preimplantation embryos. Reproduction 131(5):823-35 |
| abstractText | The maintenance of optimal glucose utilization during the preimplantation period is critical for embryo survival. A decrease in glucose transport during preimplantation development has been linked to the early steps of programmed cell death in these embryos. Decreased glucose transport is not thought to be simply a consequence of cell death, rather it is thought to be a trigger that can initiate the apoptotic cascade. Extensive apoptosis during the preimplantation period may manifest later in pregnancy as a malformation-- or miscarriage, if cell loss is excessive. Phosphatidylinositol 3-kinase (PI3-K) is a known regulator of a number of physiologic responses including cellular proliferation, growth, and survival as well as glucose metabolism. Studies performed in other cell systems have demonstrated that the PI3-K pathway plays a critical role in maintaining glucose transport and metabolism. This review will present the current evidence that suggests that PI3-K is vital for preimplantation embryo survival and development. In addition, data demonstrating that PI3-K activity is important for glucose metabolism during this early developmental period will be discussed. |
