| Type | MGI:General | Description | 3-5 month old null mice exhibit a spatial learning deficit as shown by longer latencies to locate a hidden platform in the initial acquisition phase in the first probe trial with an absent platform conducted 24 hours after the acquisiton trials, null mice display less selective searching behavior for an absent platform and less time in the target quadrant (40% for control, 27% for nulls); on reversal trials with the platform in a new location, null animals have longer escape latencies than control over the course of 12 trials in a second probe trial with the platform removed, the time spent in the target quadrant by null mice is 31% compared to 50% by controls and had a reduced number of annulus crossings through the former location of the platform in trials with a visual cue of the platform location, null mice showed longer escape latencies during trials 4-12, then showed similar performance to conrols |
