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Publication : Mammalian P4-ATPases and ABC transporters and their role in phospholipid transport.

First Author  Coleman JA Year  2013
Journal  Biochim Biophys Acta Volume  1831
Issue  3 Pages  555-74
PubMed ID  23103747 Mgi Jnum  J:198868
Mgi Id  MGI:5499681 Doi  10.1016/j.bbalip.2012.10.006
Citation  Coleman JA, et al. (2013) Mammalian P4-ATPases and ABC transporters and their role in phospholipid transport. Biochim Biophys Acta 1831(3):555-74
abstractText  Transport of phospholipids across cell membranes plays a key role in a wide variety of biological processes. These include membrane biosynthesis, generation and maintenance of membrane asymmetry, cell and organelle shape determination, phagocytosis, vesicle trafficking, blood coagulation, lipid homeostasis, regulation of membrane protein function, apoptosis, etc. P(4)-ATPases and ATP binding cassette (ABC) transporters are the two principal classes of membrane proteins that actively transport phospholipids across cellular membranes. P(4)-ATPases utilize the energy from ATP hydrolysis to flip aminophospholipids from the exocytoplasmic (extracellular/lumen) to the cytoplasmic leaflet of cell membranes generating membrane lipid asymmetry and lipid imbalance which can induce membrane curvature. Many ABC transporters play crucial roles in lipid homeostasis by actively transporting phospholipids from the cytoplasmic to the exocytoplasmic leaflet of cell membranes or exporting phospholipids to protein acceptors or micelles. Recent studies indicate that some ABC proteins can also transport phospholipids in the opposite direction. The importance of P(4)-ATPases and ABC transporters is evident from the findings that mutations in many of these transporters are responsible for severe human genetic diseases linked to defective phospholipid transport. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism.
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