Primary Identifier | MGI:1918478 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 71228 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable beta-catenin binding activity and cytoskeletal protein binding activity. Involved in several processes, including positive regulation of dendritic spine development; positive regulation of synapse assembly; and regulation of signal transduction. Acts upstream of or within several processes, including apical protein localization; epithelial cell differentiation; and protein localization to adherens junction. Located in adherens junction and ciliary basal body. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; lung; and nervous system. Orthologous to human DLG5 (discs large MAGUK scaffold protein 5). PHENOTYPE: Mice homozygous for a null allele exhibit growth retardation, hydroencephaly, abnormal brain morphology, abnormal neurogenesis, kidney cysts, ureter defects, and abnormal kidney morphology. [provided by MGI curators] |