| First Author | Kooy RF | Year | 1996 |
| Journal | Am J Med Genet | Volume | 64 |
| Issue | 2 | Pages | 241-5 |
| PubMed ID | 8844056 | Mgi Jnum | J:34449 |
| Mgi Id | MGI:81907 | Doi | 10.1002/(SICI)1096-8628(19960809)64:2<241::AID-AJMG1>3.0.CO;2-X |
| Citation | Kooy RF, et al. (1996) Transgenic mouse model for the fragile X syndrome. Am J Med Genet 64(2):241-5 |
| abstractText | Transgenic fragile X knockout mice have been constructed to provide an animal model to study the physiologic function of the fragile X gene (FMR1) and to gain more insight into the clinical phenotype caused by the absence of the fragile X protein. Initial experiments suggested that the knockout mice show macroorchidism and cognitive and behavioral deficits, abnormalities comparable to those of human fragile X patients. In the present study, we have extended our experiments, and conclude that the Fmr1 knockout mouse is a reliable transgenic model to study the fragile X syndrome. |
