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Allele : Tardbp<em1Rhbr> TAR DNA binding protein; endonuclease-mediated mutation 1, Robert Brown Jr

Primary Identifier  MGI:6157626 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence Gene  Tardbp
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/Cas9 methodologies were used to introduce a 1 bp base pair mutation (C>A) resulting in a Q331K point mutation. The Q331K mutation is associated with Amyotrophic Lateral Sclerosis.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • TDP-43<Q331K>,
  • TDP-43<Q331K>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

Trail: Allele

0 Driven By

6 Publication categories

Trail: Allele