| First Author | Tsunoda N | Year | 1998 |
| Journal | Metabolism | Volume | 47 |
| Issue | 6 | Pages | 724-30 |
| PubMed ID | 9627373 | Mgi Jnum | J:48046 |
| Mgi Id | MGI:1261672 | Doi | 10.1016/s0026-0495(98)90037-3 |
| Citation | Tsunoda N, et al. (1998) High-monounsaturated fat diet-induced obesity and diabetes in C57BL/6J mice. Metabolism 47(6):724-30 |
| abstractText | A high-monounsaturated fat diet has been proposed as a palatable alternative to a high-carbohydrate diet in diabetic patients, but it is unknown whether a higher intake of monounsaturated fat induces obesity and diabetes, as usually observed with other types of fat. To answer this question, C57BL/6J mice were divided into three groups: the first group was given a high-carbohydrate diet, and the other two groups were given a high-monounsaturated fat diet (60% of total energy) as olive oil or synthetic triolein for 4 months. It has been previously reported that the C57BL/6J mouse has a genetic predisposition for intraabdominal obesity and non-insulin-dependent diabetes mellitus (NIDDM) by high-polyunsaturated fat (n-6) feeding. Although there were no significant differences in energy intake and fat absorption among these three groups, compared with the high-carbohydrate diet, both high-monounsaturated fat diets produced hyperglycemia, obesity, and triglyceride accumulation in the liver and skeletal muscle. These data indicate that the recently recommended high-monounsaturated fat diet might induce obesity and diabetes. |
