| First Author | Mendel I | Year | 1999 |
| Journal | J Neuroimmunol | Volume | 96 |
| Issue | 1 | Pages | 9-20 |
| PubMed ID | 10227420 | Mgi Jnum | J:100211 |
| Mgi Id | MGI:3588340 | Doi | 10.1016/s0165-5728(99)00009-0 |
| Citation | Mendel I, et al. (1999) Experimental autoimmune encephalomyelitis induced in B6.C-H-2bm12 mice by myelin oligodendrocyte glycoprotein: effect of MHC class II mutation on immunodominant epitope selection and fine epitope specificity of encephalitogenic T cells. J Neuroimmunol 96(1):9-20 |
| abstractText | The effect of the bm12 mutation on susceptibility to MOG-induced EAE, TCR repertoire and fine epitope specificity of the encephalitogenic T-cells, was assessed. prMOG35-55 was encephalitogenic for H-2bm12 and H-2b mice. Despite only minor differences in TCRVbeta expression and fine epitope specificity, H-2bm12/ and H-2b/prMOG35-55-specific T-cells failed to recognize Ab/prMOG35-55 and Abm12/prMOG35-55, respectively. rhMOG-induced EAE was milder in H-2bm12 mice, possibly as a result of co-dominant responses to prMOG35-55 and to the non-encephalitogenic pMOG94-116, rather than a single dominant response to prMOG35-55 in H-2b mice. |
