Primary Identifier | IPR037964 | Type | Family |
Short Name | MTA2 |
description | Metastasis-associated protein MTA2 is a component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD) []. It is a member of the MTA family.MTA (metastasis-associated) family members, including MTA1-3, are transcriptional co-repressors that function in histone deacetylation and are involved in the NuRD complex. Nevertheless, MTA1 and MTA2 have been shown to deacetylate non-histone proteins, such as p53. The expression of the MTA family members have been linked to human cancers []. |