| Type | MGI:General | Description | in vivo, no L-Trp-dependent release of insulin is observed 10 minutes after oral dosing as determined by plasma insulin levels; in contrast, oral dosing of L-Trp rapidly and dose-dependently increases plasma insulin levels in wild-type controls reaching peak concentrations at 5-10 minutes after dosing L-Phe-induced insulin release is blunted, as determined by plasma insulin levels at 10 minutes after oral dosing compound A (a synthetic GPR142 agonist)-induced insulin release is absent, as determined by plasma insulin levels at 30 minutes after oral dosing |
