| First Author | Dolfi DV | Year | 2008 |
| Journal | J Immunol | Volume | 180 |
| Issue | 5 | Pages | 2912-21 |
| PubMed ID | 18292513 | Mgi Jnum | J:131571 |
| Mgi Id | MGI:3773974 | Doi | 10.4049/jimmunol.180.5.2912 |
| Citation | Dolfi DV, et al. (2008) Late Signals from CD27 Prevent Fas-Dependent Apoptosis of Primary CD8+ T Cells. J Immunol 180(5):2912-21 |
| abstractText | The role of costimulation has previously been confined to the very early stages of the CD8(+) T cell response. In this study, we demonstrate the requirement for CD27 costimulation during the later phase, but not programming of the primary CD8(+) T cell response to influenza virus and reveal a novel mechanism of action for CD27 costimulation. CD27 signals, during the later phase of the primary CD8(+) T cell response, prevent apoptosis of Ag-specific CD8(+) T cells. Blocking CD27L (CD70) on days 6 and 8 after infection reduces the number of NP((366-374))-specific CD8(+) T cells, increases their sensitivity to CD95/Fas-mediated apoptosis, and up-regulates FasL on CD4(+) T cells. This reduction of NP((366-374))-specific CD8(+) T cells requires the presence of CD4(+) T cells and Fas signaling. Lack of CD27 signals also decreases the quality of memory CD8(+) T cell responses. Memory CD8(+) T cells, which express surface CD27 similar to naive cells, however, do not require CD27 costimulation during a secondary response. Thus, CD27 acts indirectly to regulate primary Ag-specific CD8(+) T cell responses by preventing apoptosis of CD8(+) T cells during the later phase of the primary response and is required for optimal quality of memory cells, but is not required during normally primed secondary CD8(+) T cell responses. |
